Andrew Kaulder (Scoot McNairy) is an American photojournalist on assignment in Mexico at a time when working there has become unusually dangerous - after a NASA space probe crash-landed not far from the American border, alien creatures that made their way into the satellite were released, and have since thrived in Northern Mexico. Now the area is regarded as an "infected zone," where the aliens (who resemble giant squids) have been contained but move about freely, sometimes attacking humans who cross their paths. While working on a project, Kaulder's publisher contacts him to ask a big favor; his daughter Samantha (Whitney Able) has been traveling outside the United States, and would appreciate an escort from Southern Mexico to California.
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